The Longevity Expert The weekly longevity podcast for people over 35 who want the science, not the hype. Each episode breaks down one peer-reviewed finding that changes how you should think about aging: heart health, muscle and strength, metabolism, brain health, supplements, and the biomarkers your doctor never explains. No influencer hot takes. No 30-step routines. Just what the evidence actually says, and how strong that evidence really is, in about 10 minutes. The podcast is the science half. The newsletter is where it becomes something you actually do. Every episode comes from The Longevity Expert, a free weekly newsletter that goes further than the show: the exact protocol, the doses, the tests to ask for, and the mistakes to avoid. Read it and subscribe free here: https://thelongevityexperts.beehiiv.com Hosted by Dave. Educational content only, not medical advice. https://thelongevityexperts.beehiiv.com/ en © 2026 The Longevity Expert 019f710a-8b2d-726e-829f-26a1adbac750 no podcast https://media.beehiiv.com/cdn-cgi/image/fit=scale-down,format=auto,onerror=redirect,quality=80/uploads/asset/file/84b25011-8ef5-44cc-9933-a029bc059c83/the_longevity_expert_podcast.png?t=1784308376 The Longevity Expert https://thelongevityexperts.beehiiv.com/ false episodic The Longevity Expert The weekly longevity podcast for people over 35 who want the science, not the hype. Each episode breaks down one peer-reviewed finding that changes how you should think about aging: heart health, muscle and strength, metabolism, brain health, supplements, and the biomarkers your doctor never explains. No influencer hot takes. No 30-step routines. Just what the evidence actually says, and how strong that evidence really is, in about 10 minutes. The podcast is the science half. The newsletter is where it becomes something you actually do. Every episode comes from The Longevity Expert, a free weekly newsletter that goes further than the show: the exact protocol, the doses, the tests to ask for, and the mistakes to avoid. Read it and subscribe free here: https://thelongevityexperts.beehiiv.com Hosted by Dave. Educational content only, not medical advice.

]]> The Longevity Expert the.longevity.expert@gmail.com Sun, 02 Aug 2026 22:54:56 +0000 Sun, 02 Aug 2026 23:42:47 +0000 beehiiv The enzyme that eats your NAD https://thelongevityexperts.beehiiv.com/podcast/s/the_longevity_expert/the_enzyme_that_eats_your_nad Everyone talks about raising NAD. Almost nobody talks about losing it. An enzyme called CD38 is the main reason NAD falls with age, and it degrades the NMN you take as well as the NAD itself. Remove CD38 in mice and the age-related decline largely disa... Sun, 02 Aug 2026 22:54:56 +0000 444 The Longevity Expert false full 4 1 Everyone talks about raising NAD. Almost nobody talks about losing it. An enzyme called CD38 is the main reason NAD falls with age, and it degrades the NMN you take as well as the NAD itself. Remove CD38 in mice and the age-related decline largely disappears. This week: the other half of the NAD equation.

In this episode:

  • The 2016 Cell Metabolism study that reframed NAD decline as a destruction problem

  • Why CD38 knockout mice show no age-related NAD decline at all

  • The detail that matters if you supplement, and why it does not mean NMN stops working

  • Why a daily precursor is basic housekeeping, and what it does not touch

  • How chronic inflammation and senescent cells hold the drain open

  • An honest read on apigenin, including the human evidence

This episode covers the science. The full protocol is in this week's newsletter, including the levers that lower CD38 with human evidence behind them and a 30-day plan.

Read the full protocol: The enzyme that eats your NAD

Precision Longevity, 20% off for readers: $71.96 with the reader link

Contains wheat, since the spermidine is derived from wheat germ. Apigenin inhibits cytochrome P450 enzymes and can interact with common medications. If you take prescription drugs, consult your doctor or pharmacist before adding a concentrated apigenin supplement. Do not change any prescribed treatment based on a podcast.

The Longevity Expert is an evidence-based newsletter on healthy aging. This podcast is for educational purposes only and is not medical advice.

]]> What cold plunges actually do and do not do https://thelongevityexperts.beehiiv.com/podcast/s/the_longevity_expert/what_cold_plunges_actually_do_and_do_not_do Cold plunges are one of the most hyped wellness trends of the decade: burn fat, fix your metabolism, spike testosterone, transform your mood. This week we went to the actual evidence, and the honest picture is more interesting than the hype. Some benef... Mon, 27 Jul 2026 01:37:35 +0000 427 The Longevity Expert false full 3 1 Cold plunges are one of the most hyped wellness trends of the decade: burn fat, fix your metabolism, spike testosterone, transform your mood. This week we went to the actual evidence, and the honest picture is more interesting than the hype. Some benefits are real, several of the biggest claims collapse under scrutiny, and for anyone over 50 focused on preserving muscle there is a specific timing mistake that quietly works against you.

In this episode:

  • What cold water immersion genuinely does for mood, stress, and sleep, and why the effect is real

  • Why the fat-loss, metabolism, and testosterone claims fall apart under the evidence

  • The timing mistake that blunts muscle growth, and why it matters most after 50

  • The mechanism: how the same thing that makes cold feel good also interferes with building muscle

  • An honest confidence rating, high for one effect, low for the claims that sell the tubs

  • Who should be cautious for cardiovascular safety reasons

This episode covers the science. The full protocol is in this week's newsletter: how to use cold correctly if you enjoy it, the one timing rule that protects your muscle, who should avoid it on safety grounds, the common pitfalls, and a 30-day plan.

Read the full protocol: What cold plunges actually do and do not do

Subscribe to the free weekly newsletter: The Longevity Expert

Cold immersion causes a sharp spike in heart rate and blood pressure. If you have cardiovascular disease, high blood pressure, a heart rhythm disorder, or a history of cardiac events, talk to your doctor before cold plunging. Never plunge alone in open water. This podcast is for educational purposes only and is not medical advice.

The Longevity Expert is an evidence-based newsletter on healthy aging.

]]> Why fish oil failed the Alzheimer's trials https://thelongevityexperts.beehiiv.com/podcast/s/the_longevity_expert/why_fish_oil_failed_the_alzheimer_s_trials For twenty years the observational data was clear: people who ate more fish had lower rates of Alzheimer's disease. Then the trials came back negative, and fish oil was quietly written off. But those trials tested omega-3 in people who already had the ... Mon, 20 Jul 2026 12:34:52 +0000 597 The Longevity Expert false full 2 1 For twenty years the observational data was clear: people who ate more fish had lower rates of Alzheimer's disease. Then the trials came back negative, and fish oil was quietly written off. But those trials tested omega-3 in people who already had the disease, and amyloid begins accumulating in the brain one to two decades before the first symptom appears. This week, the timing hypothesis, and what it changes about protecting your brain.

In this episode:

  • Why the omega-3 Alzheimer's trials failed, and what everyone missed about who was in them

  • The timing hypothesis: why amyloid builds for 15 to 20 years before the first symptom

  • The APOE4 gene variant and the brain DHA transport problem affecting a quarter of the population

  • What the 2024 Lancet Commission found: 14 modifiable risk factors, close to half of all dementia cases

  • Why DHA is a building material, not a drug, and what that means for when you start

  • An honest read on the evidence, including the limitations nobody mentions

This episode covers the science. The full protocol is in this week's newsletter: the omega-3 index target and how to test it at home, the dose and formulation that matter for the brain versus mood, the prevention levers ranked by actual impact, the three common mistakes, and a simple 30-day plan.

Read the full protocol: Why fish oil failed the Alzheimer's trials

Subscribe to the free weekly newsletter: The Longevity Expert

If you are noticing memory changes, speak with a doctor rather than self-managing. High-dose omega-3 can increase bleeding risk and interacts with anticoagulants like warfarin, so check with your doctor before starting. Do not stop or change any prescribed medication based on a podcast.

The Longevity Expert is an evidence-based newsletter on healthy aging. This podcast is for educational purposes only and is not medical advice.

]]> Is Depression an Inflammatory Disease? https://thelongevityexperts.beehiiv.com/podcast/s/the_longevity_expert/is_depression_an_inflammatory_disease For decades, depression was explained as a chemical imbalance in the brain. That story is now looking incomplete. In 2025, researchers at Emory University formally proposed that for a meaningful subset of people, depression is driven by inflammation yo... Fri, 17 Jul 2026 18:12:05 +0000 513 The Longevity Expert false full 1 1 For decades, depression was explained as a chemical imbalance in the brain. That story is now looking incomplete. In 2025, researchers at Emory University formally proposed that for a meaningful subset of people, depression is driven by inflammation you can measure in the blood. These patients show elevated inflammatory markers, a distinct symptom pattern, and, critically, they respond poorly to standard antidepressants.

In this first episode, Dave breaks down what the evidence actually shows: why one in three people don't respond to standard treatment, the three findings behind the inflammatory subtype, and the elegant mechanism connecting your immune system to your mood.

In this episode:

  • Why depression may not be one disease, but at least two

  • What "sickness behavior" is, and why this depression looks more like fighting the flu than sadness

  • How a cheap, standard blood test (hs-CRP) can tell you if inflammation is part of your picture

  • What the research says about which treatments work better when inflammation is high

  • The honest limits: who this applies to, and who it doesn't

This episode covers the science. The full protocol, the exact test to ask for, the omega-3 dose and formulation the trials used, the exercise prescription, and the 30-day plan, is in this week's newsletter.

Read the full protocol: Is Depression an Inflammatory Disease? What the Evidence Shows

Nothing in this episode replaces psychiatric care. If you are on an antidepressant, do not stop or change it based on a podcast. If you are having thoughts of harming yourself, please reach out for help right away. In the United States, call or text 988 any time.

The Longevity Expert is an evidence-based newsletter on healthy aging. This podcast is for educational purposes only and is not medical advice.

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